July 11, Tuesday
Opening Remarks
| 8:00-8:10 | Yoshinori Murakami (National Cancer Center, Japan) |
Introductory Address
Chairperson: Roger H. Reeves| 8:10-8:20 | Yasuhiko Kurosawa (The Fujihara Foundation of Science) Susumu Nishimura (The Fujihara Foundation of Science) |
Keynote Lecture
Chairperson: Eric J. Stanbridge| 8:20-9:00 | L-1 Yoshinori Murakami (National Cancer Center, Japan) Tumor suppressor function of TSLC1/IGSF4 as an epithelial guardian |
Session IA Oncogenesis
Chairperson: Peter Bradding and Douglas P. Clark| 9:00-9:25 | S1-1 Maria L. Lung (Hong Kong University of Science and
Technology, Hong Kong) Identification and functional studies of TSLC1 in nasopharynageal carcinoma |
| 9:25-9:50 | S1-2 Akiteru Goto (University of Tokyo, Japan) Loss of TSLC1/IGSF4 expression in lung adenocarcinoma: relationships with gender and prognostic significance |
| 9:50-10:15 | S1-3 Robert Winqvist (University of Oulu, Finland) Analysis of TSLC1 and other chromosome 11q21-q24 loss of heterozygosity candidate target genes in human breast cancer |
| 10:15-10:35 | Coffee Break |
Special Lecture I
Chairperson: Yoshimi Takai| 10:35-11:05 | L-2 Minoru Toyota (Sapporo Medical University, Japan) DNA methylation changes in cancer: application to diagnosis and therapy |
Session IB Oncogenesis
Chairperson: Robert Winqvist and Akihiko Ito| 11:05-11:30 | S1-4 Yutaka Shimada (Kyoto University, Japan) Downstream mechanisms of TSLC1 in esophageal cancer |
| 11:30-11:55 | S1-5 Renske D. M. Steenbergen (VU University, Netherlands) Dense TSLC1 promoter hypermethylation in cervical squamous cell carcinomas but not adenocarcinomas |
| 11:55-12:20 | S1-6 Douglas P. Clark (Johns Hopkins University, USA) TSLC1/IGSF4 DNA Methylation as a Biomarker of Cervical and Anal Carcinoma |
| 12:20-12:35 | Round Table Discussion II |
| 12:50-14:10 | Lunch |
Special Lecture II
Chairperson: Yoshinori Murakami| 14:30-15:10 | L-3 Yoshimi Takai (Osaka University, Japan) Nectin and nectin-like molecules in cell adhesion, movement, and proliferation |
Session II Roles in Epithelia
Chairperson: Kazuhiro Morishita and Hara P. Ghosh| 15:10-15:35 | S2-1 Hara P. Ghosh (McMaster University, Canada) Studies on the TSLC1 tumor suppressor in lung cancer gene |
| 15:35-15:50 | S2-2 Mari Masuda (National Cancer Center, Japan) TSLC1 suppresses epithelial cell scattering and tubulogenesis |
| 15:50-16:05 | Round Table Discussion II |
| 16:05-16:25 | Coffee Break |
Session III Synapse and nerve system
Chairperson: Albert Zlotnik and Shoichi Iseki| 16:25-16:50 | S3-1 Shinji Fushiki (Kyoto Prefectural University of
Medicine, Japan) Spatiotemporal patterns of expression of IGSF4 in developing mouse brain, with reference to the prenatal effects of ionizing radiation |
| 16:50-17:15 | S3-2 Katsuhiko Tabuchi (University
of Texas, USA) Cell adhesion by SynCAM and Neurexin/Neuroligins drive functional synapse assembly |
| 17:15-17:40 | S3-3 Albert Zlotnik (Neurocrine Biosciences, USA) Characterization of CRTAM, ligand of IGSF4 |
| 17:40-17:55 | Round Table Discussion III |
| 18:15-18:30 | Group Photograph |
| 18:30-20:30 | Reception |
| 20:30-21:30 | Poster session A |
July 12, Wednesday
Session IV Immune response
Chairperson: Wei Yan and Takashi Saito| 8:00-8:25 | S4-1 Marco Colonna (Washington University, USA) The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM |
| 8:25-8:50 | S4-2 Laurent Galibert (Amgen Inc., USA) Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule |
| 8:50-9:15 | S4-3 Takashi Saito (RIKEN, Japan) Function of CRTAM-TSLC1/Necl2 interaction in in vivo immunity |
| 9:15-9:40 | S4-4 Kazuhiro Morishita (University of Miyazaki, Japan) TSLC1 is a novel and useful surface marker for adult T-cell leukemia |
| 9:40-9:55 | Round Table Discussion IV |
| 9:55-10:15 | Coffee Break |
Special Lecture III
Chairperson: Yukihiko Kitamura| 10:15-10:55 | L-4 John Bienenstock (McMaster University, Canada) Overview of nerve-mast cell interaction in vitro and in vivo, and involvement of SgIGSF/SynCAM/TSLCI in immunological synapse |
Session V Mast cell
Chairperson: John Bienenstock and Yukihiko Kitamura| 10:55-11:20 | S5-1 Tadahide Furuno (Aichi Gakuin University, Japan) The SgIGSF/SynCAM on mast cells promotes interaction with nerves |
| 11:20-11:45 | S5-2 Akihiko Ito (Kobe University, Japan) SgIGSF: a new mast-cell adhesion molecule that mediates attachment to fibroblasts under the control of c-kit |
| 11:45-12:10 | S5-3 Peter Bradding (Glenfield Hospital, UK) TSLC-1 plays a key role in the interaction of human lung mast cells with airway smooth muscle |
| 12:10-12:25 | Round Table Discussion V |
| 12:50-17:30 | Excursion |
| 18:00-20:00 | Dinner |
| 20:00-21:00 | Poster Session B |
July 13, Thursday
Session VI Spermatogenesis
Chairperson: Shinji Fushiki and Tomohiko Wakayama| 8:00-8:25 | S6-1 Tomohiko Wakayama (Kanazawa University, Japan) Role of SgIGSF/TSLC1 in the interaction between spermatogenic and Sertoli cells during mouse spermatogenesis |
| 8:25-8:50 | S6-2 Louise van der Weyden (Wellcome Trust Sanger Institute,
UK) Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis |
| 8:50-9:05 | S6-3 Daisuke Yamada (National Cancer Center, Japan) Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4 |
| 9:05-9:20 | Round Table Discussion VI |
| 9:20-9:40 | Coffee Break |
Session VII Related science
Chairperson: Maria L Lung and Reiji Kannagi| 9:40-10:05 | S7-1 Shoichi Iseki (Kanazawa University, Japan) Expression of the adhesion molecule SgIGSF/TSLC1 during regeneration of the olfactory epithelium and sciatic nerve |
| 10:05-10:30 | S7-2 Yoshikazu Kurosawa (Fujita Health University, Japan) Comprehensive isolation of antibodies bound to tumor-associated antigens (TAA) and their identification |
| 10:30-10:55 | S7-3 Roger H. Reeves (Johns Hopkins University, USA) Tumor repression in Down syndrome |
| 10:55-11:20 | S7-4 Eric J. Stanbridge (University of California, Irvine,
USA) The tumor and hypoxia biomarker carbonic anhydrase IX: its utility in monitoring HIF-1 activity |
| 11:20-11:35 | Round Table Discussion VII |
Summary
Chairperson: Roger H. Reeves, Yoshinori Murakami| 11:35-12:30 | Round Table Discussion |
Closing Remarks
Chairperson: Akihiko Ito| 12:30-12:40 | Roger H. Reeves (Johns Hopkins University, USA) |
Poster Session (July 11-July 12)
| P-1 | Mihoko Kajita (Osaka University, Japan) Necl-5/poliovirus receptor cis-interacts with integrin aVb3 and regulates its clustering and formation of focal complexes |
| P-2 | Yosuke Horikoshi (Yokohama City University, Japan) Lgl mediates apical domain disassembly by suppressing the PAR-3–aPKC–PAR-6 complex to orient apical membrane polarity |
| P-3 | Yasunori Enomoto (Nara Medical University, Japan) Correlation of TSLC1 gene expression with inflammatory activity in colon of ulcerative colitis patients. |
| P-4 | Motoi Ohba (Showa University, Japan) Disturbed cell-cell attachment by overexpression of protein kinase C η |
| P-5 | Miwako Homma (Fukushima Medical University, Japan) Regulatory role of CK2 during the progression of cell cycle |
| P-6 | Junko Oonuma (Kobe University, Japan) Cloning of a soluble isoform of SgIGSF/IGSF4 that binds the ectodomain of the membrane-bound form |
| P-7 | Daisuke Yamada (National Cancer Center, Japan) Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma. |
| P-8 | Arata Takeuchi (RIKEN, Japan) Physiological role of CRTAM expression in vivo immunity. |
| P-9 | Toshiyuki Minami (University of Miyazaki, Japan) Functional analyses of the human cell adhesion molecule TSLC1 overexpressed in adult T-cell leukemia cells |
| P-10 | Kenji Watabe (Osaka University, Japan) Distinct roles for SgIGSF adhesion molecule and c-kit receptor tyrosine kinase in mast cells adhesion to and transmigration across mesothelial cells |
| P-11 | Gene Kurosawa (Fujita Heath University, Japan) Isolation of human monoclonal antibodies specific against IGSF4 |
| P-12 | Reiji Kannagi (Aichi Cancer Center, Japan) Roles of carbohydrate side chains of immunoglobulin superfamily cell adhesion molecules (IgCAMs) |
| P-13 | Hiroshi Fukuhara (University of Tokyo, Japan) Efficient construction system of armed oncolytic herpes simplex virus vectors using a triple gene deleted backbone and bacterial artificial chromosome |
| P-14 | Kouyuki Hirayasu (University of Tokyo, Japan) Long-term persistence of both functional and non-functional alleles at the leukocyte immunoglobulin-like receptor A3 (LILRA3) locus suggests balancing selection |
| P-15 | Shingo Usui (National Cancer Center, Japan) Quantitative detection of allelic imbalance in the gene expression by an RNA difference plot |
| P-16 | Shinji Kikuchi (National Cancer Center, Japan) Inactivation of a novel tumor suppressor cascade, including TSLC1/IGSF4 and DAL-1/4/1B as key components, in human non-small cell lung cancer |
| P-17 | Yuko N. Williams (National Cancer Center, Japan) Cell adhesion and prostate tumor suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4 |
| P-18 | Mika Sakurai-Yageta (National Cancer Center, Japan) Involvement of the tumor suppressor protein, TSLC1/IGSF4 in the epithelial cell structure with DAL-1/4.1B and MPP proteins |